While Vitamin C and Vitamin E exhibit synergistic properties in regard to antioxidant activity, unless the one supplemented is truly deficient, increasing its intake also increases the requirements of the other, otherwise a pseudo-deficiency of the other, and a ratio conflict, or balance problem with nickel takes place, which can change vasodilating or vasoconstrictive properties of the coronary arteries. While this poses no problems for the average, healthy individual, it can be detrimental for those suffering from angina-related conditions.... Full Text